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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
30/06/2023 |
Actualizado : |
30/06/2023 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
GIANNITTI, F.; GARCÍA, J. P.; ADAMS, V.; ARMENDANO, J.; BEINGESSER, J.; ROOD, J.; UZAL, F. A. |
Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JORGE P. GARCÍA, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; VICKI ADAMS, Monash University, Parkville, Victoria, Australia; JOAQUÍN I. ARMENDANO, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Buenos Aires, Argentina; JULIANN BEINGESSER, California Animal Health and Food Safety Laboratoy, University of California at Davis, San Bernardino, CA; JULIAN I. ROOD, Monash University, Parkville, Victoria, Australia; FRANCISCO A. UZAL, Monash University, Parkville, Victoria, Australia. |
Título : |
Experimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions. |
Complemento del título : |
Infectious Disease - Original Article. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Veterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669 |
ISSN : |
0300-9858 (print); 1544-2217 (online). |
DOI : |
10.1177/03009858231171669 |
Idioma : |
Inglés |
Notas : |
Article history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- |
Contenido : |
ABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 MenosABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 ... Presentar Todo |
Palabras claves : |
Clostridium perfringens type D; Enterotoxemia; ETX; Experimental infection; Kidneys; PLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA; Renal pathology; Sheep. |
Asunto categoría : |
L10 Genética y mejoramiento animal |
Marc : |
LEADER 03352naa a2200325 a 4500 001 1064216 005 2023-06-30 008 2023 bl uuuu u00u1 u #d 022 $a0300-9858 (print); 1544-2217 (online). 024 7 $a10.1177/03009858231171669$2DOI 100 1 $aGIANNITTI, F. 245 $aExperimental acute Clostridium perfringens type D enterotoxemia in sheep is not characterized by specific renal lesions.$h[electronic resource] 260 $c2023 500 $aArticle history: First published online May 12, 2023. -- Corresponding Author: Francisco A. Uzal, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California at Davis, 105 W CVentral Ave, San Bernardino, CA 92408, USA. Email: fauzal@ucdavis.edu -- Funding: This work was supported by grant R01 AI056177 from the National Institute of Allergy and Infectious Diseases (NIAID). Research at Monash University was also supported by funding provided by the Australian Research Council to the Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics (grant no. CE0562063). -- 520 $aABSTRACT.- Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease". Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringens type D strain, an etx knockout mutant unable to produce ETX, the etx mutant strain complemented with the wild-type etx gene that regains the ETX toxin production, or sterile culture medium (control group). All sheep were autopsied less than 24 hours after inoculation; none of them developed gross lesions in the kidneys. Ten predefined histologic renal changes were scored in each sheep. The proportion of sheep with microscopic changes and their severity scores did not differ significantly between groups. Mild intratubular medullary hemorrhage was observed in only 2 of the 12 sheep inoculated with the wild-type or etx-complemented bacterial strains, but not in the 12 sheep of the other 2 groups. The authors conclude that no specific gross or histologic renal lesions are observed in sheep with experimental acute type D enterotoxemia. © The Author(s) 2023 653 $aClostridium perfringens type D 653 $aEnterotoxemia 653 $aETX 653 $aExperimental infection 653 $aKidneys 653 $aPLATAFORMA DE INVESTIGACIÓN EN SALUD ANIMAL - INIA 653 $aRenal pathology 653 $aSheep 700 1 $aGARCÍA, J. P. 700 1 $aADAMS, V. 700 1 $aARMENDANO, J. 700 1 $aBEINGESSER, J. 700 1 $aROOD, J. 700 1 $aUZAL, F. A. 773 $tVeterinary Pathology. 2023, vol.60(4):412-419. https://doi.org/10.1177/03009858231171669
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5. | | CARRACELAS, B.; NAVAJAS, E.; VERA, B.; CIAPPESONI, G. Estudio de asociación de genoma completo para resistencia genética a nematodos gastrointestinales en ovinos Corriedale. [abstract]. In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Una Sola Salud (Single Health Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.96. (Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1) Corresponding author: B. Carracelas, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 48 Km 10, Las Brujas, Uruguay, mailto: bcarracelas@inia.org.uyTipo: Abstracts/Resúmenes |
Biblioteca(s): INIA Las Brujas. |
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9. | | CARRACELAS, B.; NAVAJAS, E.; VERA, B.; CIAPPESONI, G. SNP arrays evaluation as tools in genetic improvement in Corriedale sheep in Uruguay. [Evaluación de paneles de SNP como herramientas en la mejora genética de ovinos Corriedale en Uruguay]. [Avaliação de painéis de SNP como ferramentas em melhoramento genético de ovinos Corriedale no Uruguai]. Animal production and pastures. Agrociencia Uruguay, 2022, vol. 26, number 2, article e998. doi: https://doi.org/10.31285/AGRO.26.998 Article history: Received 09 Feb 2022; Accepted 30 May 2022; Published 19 Aug 2022. Editor: Mariana Carriquiry, Universidad de la República, Facultad de Agronomía, Montevideo, Uruguay. Correspondence: Beatriz Carracelas,...Tipo: Artículos en Revistas Indexadas Nacionales | Circulación / Nivel : Nacional - -- |
Biblioteca(s): INIA Las Brujas. |
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11. | | VERA, B.; DE BARBIERI, I.; FERREIRA, G.; NAVAJAS, E.; CARRACELAS, B.; CIAPPESONI, G. Asignación de parentesco y detección de superfecundación heteropaternal en ovinos Merino Australiano mediante paneles de SNP. In: AUPA, Proceedings del VII Congreso Uruguayo de Producción Animal. Sección Cambio Climático y Producción Sostenible (Climate Change Section), 14 y 15 diciembre 2021. Archivos Latinoamericanos de Producción Animal, 29(Supl.1), p.85-87. (Archivos Latinoamericanos de Producción Animal, Vol.29, Supl.1) Corresponding author: B. Vera, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 48 km 10, Las Brujas (Uruguay), mailto: bvera@inia.org.uyTipo: Trabajos en Congresos/Conferencias |
Biblioteca(s): INIA Las Brujas. |
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13. | | MEDEROS, A.; GALARRAGA, D.; CARRACELAS, B.; PIMENTEL, S.; LOPEZ, F.; MORENO, L.; BOVE, R. Campylobacteriosis genital bovina: importancia del monitoreo previo al entore. Revista INIA, 2014, no. 38, p. 16-20Tipo: Artículos en Revistas Agropecuarias |
Biblioteca(s): INIA Tacuarembó. |
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14. | | MEDEROS, A.; CARRACELAS, B.; MINHO, A.P.; FERNÁNDEZ, S.; SÁNCHEZ, J. Prevalence and Factors Associated with Anthelmintic Resistance in Gastrointestinal Nematodes of Cattle: A Systematic Review and Meta-analysis. Journal of Veterinary Medicine and Health, v. 2, no. 2, 2018. OPEN ACCESS. Article history: Received November 21, 2018; Accepted December 02, 2018; Published December 17, 2018.Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
Biblioteca(s): INIA Tacuarembó. |
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15. | | CIAPPESONI, G.; NAVAJAS, E.; BAPTISTA, R.; AGUILAR, I.; PERAZA, P.; CARRACELAS, B.; DE BARBIERI, I. Proyecto SMARTER. INIA ya está en el Mundial de la Genética Ovina. Producción Animal. Revista INIA Uruguay, Marzo 2022, no.68, p.15-18. (Revista INIA; 68).Tipo: Artículos en Revistas Agropecuarias |
Biblioteca(s): INIA Las Brujas. |
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16. | | VERA, B.; MONZALVO, C.; NAVAJAS, E.; DE BARBIERI, I.; CARRACELAS, B.; VAN LIER, E.; CIAPPESONI, G. Predicción del valor genético de ovinos en predios comerciales para emisión de metano, eficiencia de conversión y características productivas. Revista INIA Uruguay, Diciembre 2022, no.71, p. 34-37. (Revista INIA; 71)Tipo: Artículos en Revistas Agropecuarias |
Biblioteca(s): INIA Treinta y Tres. |
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17. | | MEDEROS, A.; BANCHERO, G.; MONTOSSI, F.; ISASA, F.; CARRACELAS, B.; CRUDELI, M. Uso de extractos de taninos de quebracho (Shinopsis Spp) en el control de parásitos gastrointestinales de los ovinos en pastoreo. ln: INIA Tacuarembó. Unidad Experimental Glencoe. Día de Campo Unidad Experimental Glencoe [Colonia Fernando Baccaro, Guarapirú, Paysandú], 2012. Propuestas tecnológicas para sistemas ganaderos de Basalto. Tacuarembó (Uruguay): INIA, 2012. p. 18-20 (INIA Serie Actividades de Difusión ; 693)Biblioteca(s): INIA Tacuarembó. |
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18. | | CARRACELAS, B.; PERAZA, P.; VERGARA, A.; CIAPPESONI, G.; RAVAGNOLO, O.; AGUILAR, I.; LEMA, O.M.; NAVAJAS, E. Banco de ADN genómico animal - plataforma de evaluación genómica. Revista INIA Uruguay, Diciembre 2022, no.71, p. 38-42. (Revista INIA; 71)Tipo: Artículos en Revistas Agropecuarias |
Biblioteca(s): INIA Treinta y Tres. |
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19. | | MEDEROS, A.; GALARRAGA, D.; CARRACELAS, B.; PIMENTEL, J.; MORENO, L.; ALVEZ, A.; BOVE, R.; LÓPEZ, F.; PERERA, C. Diagnóstico y control de Campylobacteriosis genital bovina. In: Seminario de Actualización Técnica: Entore planificado: +terneros+$ (2015, Tacuarembó, Uruguay), [Presentación oral] UY, INIA Tacuarembó. 23 de Octubre 2015.Tipo: Presentaciones Orales |
Biblioteca(s): INIA Tacuarembó. |
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20. | | RUGGIA, A.; CARRACELAS, B.; CIAPPESONI, G.; DEL PINO, M.L.; DEVINCENZI, T.; MONTALDO, S.; CARRIQUIRY, M.; NAVAJAS, E. Núcleo Informativo Hereford de INIA Las Brujas. Anuario Hereford (Montevideo), 2020, p. 214-215.Biblioteca(s): INIA La Estanzuela; INIA Tacuarembó. |
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